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Peptidase 1 (mite) (EC 3.4.22.65), also known as endopeptidase 1 (mite), is an enzyme found in various species of mites. This enzyme exhibits cysteine protease activity with broad endopeptidase specificity.The various forms of peptidase 1 pertaining to individual mite species comprise the group 1 mite allergens. Following the naming conventions of allergens, these peptidase 1 variants include Der p 1 of the European house dust mite Dermatophagoides pteronyssinus; Der f 1 of the American house dust mite Dermatophagoides farinae; Eur m 1 of the Mayne's house dust mite Euroglyphus maynei; and Pso o 1 of the sheep scab mite Psoroptes ovis. The group 1 mite allergens, especially Der p 1 and Der f 1, are major sources of house dust mite (HDM) allergies in temperate climates.

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